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What is Artesunate 60mg used for?
Used as an antimalarial medicine, Artesunate 60mg is effective against severe malaria resulting from Plasmodium falciparum. It is useful in children and adults alike during critical cases. Mostly, it is taken intramuscularly or intravenously to destroy the parasite counts, recommended especially for those who do not respond well to oral doses.
How does Artesunate 60mg work?
The medicine works on the malaria parasite by inducing free radicals in iron of the heme, causing damage to the membranes and proteins. It causes reduction of the parasites, and thus, makes it possible to clear the infection.
What are the Artesunate 60mg ingredients and available forms?
The active component in this medicine is the water-soluble hemisuccinate derivative of dihydroartemisinin i.e. Artesunate. It is provided as sterile powders in 60mg vials for injection when reconstituted.
How long does Artesunate 60mg take to act?
Peak plasma levels are achieved within minutes of administering the medicine. It begins causing parasite death almost immediately, reducing the burden of parasite count in 12 to 24 hours with the initial dose.
How long does the treatment with Artesunate 60mg last?
The dose continues for 24 hours, administered at 0, 12, and 24 hours. After this, a 3-day course is necessary for the Artemisinin-based Combination Therapy (ACT) tablet to eliminate the parasite and prevent resistance to the medicine.
What are the Artesunate 60mg benefits?
As a semi-synthetic derivative of artemisinin, Artesunate 60mg clears away parasites of malaria from the bloodstream quickly. It is more effective to treat severe malaria incidents compared to quinine and other traditional treatments. It even reduces death rates significantly with fast onset, better tolerance, and high success rates.
What is the Artesunate 60mg dosage and administration?
The usual dose is 2.4 mg/kg body weight taken intravenously or intramuscularly, starting with the first dose, and then repeated at 12 hours, and lastly again at 24 hours. Thereafter a daily dose is administered per day. Before injecting the medicine, the powder is dissolved in sodium bicarbonate. Next, it is diluted with dextrose or saline.
What are the Artesunate 60mg side effects?
The common side effects are vomiting, nausea, dizziness, and diarrhea. In some cases, after weeks of the treatment, delayed post-artesunate hemolysis (anemia) can occur in a few cases. Rare but serious effects include liver enzyme elevation temporarily, white blood cell count reduction, or severe allergic reaction.
What are precautions and contraindications of Artesunate 60mg?
Those with an allergy to Artemisinin must avoid this medicine. Keep an eye on delayed anemia for up to 4 weeks after this treatment. Do not administer this medicine in the first trimester of pregnancy. Those with kidney or liver disorders may need close monitoring by professionals.
