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What is Danazol used for?
This medicine treats hereditary angioedema, fibrocystic breast disease, and endometriosis. It manages unusual menstrual bleeding. It also reduces breast and pelvic pain. It also prevents swelling attacks in people with angioedema by suppressing ovary activity and tackling hormone levels.
How does Danazol work?
Danazol suppresses the pituitary-ovarian axis, and is a synthetic steroid. It restricts the release of gonadotropin. It also reduces the production of progesterone and estrogen. It reduces endometrial tissue growth by managing hormones. It also takes care of symptoms related to hormonal imbalance conditions, such as fibrocystic breast disease and endometriosis.
What are the Danazol ingredients and available forms?
The primary ingredient in this synthetic steroid is Danazol itself. It is distributed as oral tablet or capsule, available in strengths of 200mg, 100mg, 50mg, and so on. Inactive components usually in capsules are lactose monohydrate, gelatin, maize starch, colorants, and magnesium stearate.
How long does Danazol take to act?
The peak effect of the medicine happens in 2 to 8 hours after taking Danazol orally. Core concentration happens in 6 days with a dosing pattern of two times daily. The therapy for pain and anovulation can take 6 to 8 weeks.
How long does the treatment with Danazol last?
3 to 9 months is the usual treatment with Danazol. However, the duration of treatment will vary from a person to another, with extended lasting for people with severe endometriosis or hereditary angioedema prophylaxis.
What are the Danazol benefits?
This medicine is especially beneficial for women and their reproductive health. It relieves pelvic pain caused by endometriosis. It also treats swelling and pain in breasts for those with fibrocystic breast disease. Moreover, this product restricts repeated swelling in case of hereditary angioedema. It manages hormone imbalances and eases symptoms that impact the breast tissues and menstrual cycles.
What is the Danazol dosage and administration?
The dosing differs from one medical condition to another. For instance, 100-200mg daily dosing for mild endometriosis, going on for 3 to 9 months but following a divided dosage pattern. In moderate to severe endometriosis, daily 400mg or more. The dose is between 200mg and 300mg two to three times a day in case of hereditary angioedema, with dose adjustment in intervals.
What are the Danazol side effects?
Common side effects include weight gain, nausea, vomiting, headache, muscle cramps, acne, abnormal hair growth, voice changes, and menstrual irregularities. In rare cases, the medicine may lead to mood changes, liver toxicity, or thromboembolism.
What are Danazol's precautions and contraindications?
Contraindications are people with liver disease. Caution must be observed when using the medicine in people with lipid abnormalities, thrombotic disorders, or cancers related to hormone issues. Monitoring the treatment and dosage is essential. Regular checks for blood count, liver function, and lipid profiles may help check the treatment progress.
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